Pharmaceutical Intermediate DFS / Deferasirox CAS 201530-41-8 Treat
Product Name: Deferasirox
chemical name 4-[3,5-bis (2-hydroxyphenyl)-1,2,4-triazol-1-yl]
benzoic acid, is a kind of iron chelator products studied and
developed by the Novartis company (Swiss). It was the first
routinely used oral iron agent approved by US FDA, allowed to be
applied for the treatment of iron overloading caused by blood
transfusion in patients (older than 2 years old) of chronic anemia.
In Europe, it is recommended as the first-line treatment drug for
patients older than 6-year-old who are suffering blood iron
overload patients. In China, it is currently subject to clinical
research; Ⅱ, Ⅲ clinical trials and pharmacokinetic studies have all
shown that it has excellent safety and tolerability, and can
significantly reduce the heart, liver iron load, easy to be
accepted by the patient. At the same time, it also has
pharmacological properties of antifungal (such as Mucor which can
grow in iron-ricking environment), anti-cell proliferation,
anti-malaria, antioxidant stress injury and anti-cytotoxicity
induced apoptosis; it can be used for the treatment of
hemochromatosis, delayed skin porphyria and other diseases.
1. DFS can be used to treat the reversible renal insufficiency
caused by Fanconi syndrome.
2. It can be used for the treatment of secondary hemochromatosis.
3. It can be used for the treatment of delayed skin porphyria.
4. It can be used for the treatment of myelodysplastic syndromes.
5. It can be used for the treatment of iron overloading caused by
blood transfusion for patients (older than 2 years old) of chronic
anemia This information is compiled and edited by Ding Hong of
Precautions Patients with allergy to deferasirox are disabled.
Chemical Properties White to Off-White Solid
Usage Orally active tridentate iron chelator
Usage Biological Activity Chemical Information Tech Support &
FAQs Biological Activity Deferasirox(Exjade) is a
rationally-designed oral iron chelator. Its main use is to reduce
chronic iron overload in patients who are receiving long-term blood
Usage A tridentate chelator that binds iron with high affinity
Usage Labeled Deferasirox, intended for use as an internal standard
for the quantification of Deferasirox by GC- or LC-mass
|DNP / Sodium 2,4-dinitrophenate|
|gamma-Butyrolactone / GBL|
|4-Acetamidophenol / Paracetamol|
|Tranexamic acid / Amstat|
|Lorcaserin hydrochloride hemihydrate|
|Triamcinolone acetonide acetate|
|Adrenosterone / 11-OXO|
|Apremilast (CC-10004) / Otezla|