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Pharmaceutical Inhibitors Roflumilast / Daxas CAS 162401-32-3 Fine Chemicals

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City: Zhuhai
Province/State: Guangdong
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Pharmaceutical Inhibitors Roflumilast / Daxas CAS 162401-32-3 Fine Chemicals

Brand Name : Shuangbojie
Model Number : nutrition@chembj.com
Certification : Enterprise Standard
Place of Origin : China
MOQ : 10g
Price : Negotiation
Payment Terms : Western Union, MoneyGram, Bitocin, T/T
Supply Ability : 500kg/Month
Delivery Time : Within 24 hours
Packaging Details : Discreet Package
CAS : 162401-32-3
MF : C17H14Cl2F2N2O3
MW : 403.21
EINECS : 223-583-8
Properties : Powder
Packing : Discreet Packing
WhatsAPP : +8618578209860
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Pharmaceutical Inhibitors Roflumilast / Daxas CAS 162401-32-3 Fine Chemicals


Product Name: Roflumilast
Synonyms: ROFLUMILAST;3-(Cyclopropylmethoxy)-N-(3,5-dichloro-4-pyridinyl)-4-(difluoromethoxy)benzamide;B 9302-107;BY 217;BYK 20869;Daxas;Roflumilast / 3-(cyclopropylmethoxy)-N-(3,5-dichloropyridin-4-yl)-4-(difluoromethoxy)benzamide;3-(Cyclopropylmethoxy)-N-(3,5-dichloropyridin-4-yl)-4-(difluoromethoxy)benzamide
CAS: 162401-32-3
MF: C17H14Cl2F2N2O3
MW: 403.21
EINECS: 223-583-8


Roflumilast Usage And Synthesis


Physical and chemical properties White to light tan solid particles or crystalline powder. Odorless, slightly sweet taste, and soluble in water.


Roflumilast is a kind of oral and selective phosphodiesterase IV (PDE4) inhibitors. It is benzamides compound. And it is the only approved oral phosphatase IV (PDE-4) inhibitors that used in the treatment of respiratory diseases currently. It can selectively inhibit PDE4, block the signal transduction of inflammation, and then inhibit the damage to lung tissue caused by respiratory diseases such as COPD and asthma. It has proven to be a new mode of action in inhibiting COPD related-inflammation. Roflumilast is a once-daily tablet, and the first new type of drug for the treatment of severe COPD. It is also the first oral anti-inflammatory drugs for patients with COPD. Its unique nature can facilitate the better management of chronic obstructive pulmonary patients: when the combination with bronchodilator in the treatment of the most severe chronic obstructive pulmonary patients, roflumilast can offer the additional benefits of further reducing the symptoms and disease progression rates. Then it became the first drug of targeting particular phenotype of chronic obstructive pulmonary disease that is patients with severe airflow limitation and having a history of recurrent disease worsening associated with chronic cough and sputum.


Chemical Properties Crystallin Solid
Usage Selective phosphodiesterase 4(PDE4) inhibitor. Antiasthmatic; in treatment of chronic obstructive pulmonary disease
Usage Roflumilast (Daxas) is a selective inhibitor of PDE4 with IC50 of 0.2-4.3 nM.
Usage ophthalmic solution
Usage A selective inhibitor of phosphodiesterase 4


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