Aromatics Compounds Adrafinil CAS 63547-13-7 for Depression
Product Name: Adrafinil
Adrafinil Usage And Synthesis
Chemical Properties Light Pink Solid
Usage a-Adrenergic agonist. Treatment of depression
Usage α-Adrenergic agonist. Treatment of depression.
Because α1-adrenergic receptor antagonists were found to block
effects of adrafinil and modafinil in animals, "most investigators
assume that adrafinil and modafinil both serve as α1-adrenergic
receptor agonists." However, adrafinil and modafinil have not been
found to bind to the α1-adrenergic receptor and they lack
peripheral sympathomimetic side effects associated with activation
of this receptor; hence, the evidence in support of this hypothesis
is weak, and other mechanisms are probable. Modafinil was
subsequently screened at a variety of targets in 2009 and was found
to act as a weak, atypical blocker of the dopamine transporter (and
hence as a dopamine reuptake inhibitor), and this action may
explain some or all of its pharmacological effects. Relative to
adrafinil, modafinil possesses greater specificity in its action,
lacking or having a reduced incidence of many of the common side
effects of the former (including stomach pain, skin irritation,
anxiety, and elevated liver enzymes with prolonged use).
There is a case report of two patients that adrafinil may increase
interest in sex.
A case report of adrafinil-induced orofacial dyskinesia exists.
Reports of this side effect also exist for modafinil.
Adrafinil is a discontinued wakefulness-promoting agent (or
eugeroic) that was formerly used in France to promote vigilance
(alertness), attention, wakefulness, mood, and other parameters,
particularly in the elderly. It was also used off-label by
individuals who wished to avoid fatigue, such as night workers or
others who needed to stay awake and alert for long periods of time.
Additionally, "adrafinil is known to a larger nonscientific
audience, where it is considered to be a nootropic agent."
Adrafinil is a prodrug; it is primarily metabolized in vivo to
modafinil, resulting in very similar pharmacological effects.
Unlike modafinil, however, it takes time for the metabolite to
accumulate to active levels in the bloodstream. Effects usually are
apparent within 45–60 minutes when taken orally on an empty
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