New Androgens Aicar/Acadesine Ampk Activator Steroid Hormone CAS
1. Aicar introduction:
Product Name: AICAR/ Acadesine
Full name: 5-Aminoimidazole-4-carboxamide 1-β-D-ribofuranoside
Alias: AICA Riboside; Acadesine
Appearance: White powder
Usage: Glucose uptake stimulant; AMPK activator; AICAR is a
nucleoside analogue that is able to enter nucleoside pools and is
able to significantly increase levels of adenosine during periods
of ATP breakdown. Adenosine-regulating agents (ARAs) hav e been
recognized for therapeutic potential in myocardial ischemia.
2. Aicar Product Description:
AICAR (AICA-Riboside) strongly inhibits the transcription of
PPAR&alpha and the coactivation of PPAR&alpha. In adipocyte
studies it has been shown to antagonize lipolysis induced by
isoprenaline and has been suggested for use in kinase cascade
research. Additionally, research indicates that AICAR blocks the
differentiation of 3T3-L1 (sc-2243) adipocytes. Studies demonstrate
that AICAR can mimic the activity of insulin (sc-211647) by
activating AMPK (AMP-activated protein kinase), and affecting the
expression of PEPCK-M (PEPCK) and glucose-6-phosphatase (G6Pase).
The 5-aminoimidazole-4-carboxamide ribonucleoside (ZMP) is the
monophosphorylated derivative of AICA-Riboside, and it can serve as
the substrate for the aminoimidazole carboxamide ribonucleotide
transformylase/inosine monophosphate cyclohydrolase (ATIC). AICAR
is an inhibitor of Hsp90, mTOR and p70 S6 Kinase.
AMP-activated protein kinase (AMPK) functions as a metabolic sensor
that regulates lipid and glucose metabolism to maintain cellular
energy homeostasis and to protect against metabolic stress.AICAR is
a selective activator of AMPK in both hepatocytes and adipocytes.
At 0.5 mM it inhibits the synthesis of fatty acids and sterols and
inactivates HMG-CoA reductase in rat hepatocytes.AICAR (0.5 mM)
inhibits insulin-stimulated glucose uptake to 62% of controls and
reduces GLUT4 translocation 2.5-fold in 3T3-L1 adipocytes. It also
blocks the expression of pro-inflammatory cytokines (TNF-α/IL-1β
and IL-6), iNOS, COX-2, and MnSOD genes in glial cells and
macrophages by inhibiting NFκB and C/EBP pathways.
3. Aicar Function:
AICAR also known as ZMP is an analog of AMP that is capable of
stimulating AMP-dependent protein kinase activity (AMPK). AICAR is
being clinically used to treat and
protect against cardiac ischemic injury. If left untreated, it may
lead to a myocardial infarct.
Cardiac Ischemia is caused by insufficient blood flow and oxygen to
the myocardium .
The drug was first used in the 1980’s as a method to preserve blood
flow to the heart during surgery. Currently,
the drug has also been shown as a potential treatment for diabetes
by increasing the
metabolic activity of tissues by changing the physical composition
4. Aicar Product Application:
AICAR is a cell permeable activator of AMP-activated protein kinase
(AMPK), a metabolic master regulator that is activated in times of
reduced energy availability (high cellular AMP:ATP ratios) and
serves to inhibit anabolic processes. In vivo, pharmacologic
activation of AMPK with AICAR mimics exercise and triggers
insulin-independent glucose uptake by skeletal muscle.
Cell-permeable, allosteric activator of AMP-activated protein
kinase (AMPK). Augments proliferation, differentiation and
mineralization of osteoblastic MC3T3-EI cells and attenuates
psychosine-induced expression of proinflammatory cytokines and iNOS
in astrocytes. Promotes osteogenic differentiation of hAMSCs and
5. AICAR Test Report(COA):
|Related substance (HPLC)||Total impurity ≤0.5%|
Max single impurity ≤0.1%
|Sieve analysis||100% pass 80 mesh||Complies|
|Loss on Drying|
Residue on Ignition
|Total Plate Count||<1000cfu/g||Complies|
|Yeast & Mold||<100cfu/g||Complies|
6. What Is The Acadesine/AICAR/GP 1-110?
Acadesine (INN), also known as
and AICAR, is an AMP-activated protein kinase activator which is
used for the treatment of acute lymphoblastic leukemia and may have
applications in treating other disorders such as diabetes.
Acadesine is an adenosine regulating agent developed by PeriCor
Therapeutics and licensed to Schering-Plough in 2007 for phase III
studies. The drug is a potential first-in-class agent for
prevention of reperfusion injury in CABG surgery. Schering began
patient enrollment in phase III studies in May, 2009. The trial was
terminated in late 2010 based on an interim futility analysis.
7. What Benefits of our Acadesine/AICAR/GP 1-110?
1.Applied in phamaceutical field, it is used as phamaceutical raw
material to treat injuries from fall, infectious hepatitis and
epidemic cerebrospinal meningitis.
2.Applied in healthcare field, it is used in the health products to
nourish brain, protect liver and improve sleep quality.
3.Applied in comestics, it is used to promote skin metabolism and
make skin more tender and firm.
8. Aicar Package&Storage:
5.0 kgs/Al-foil bag
or upon customers' request.
|Storage||Store in a well-closed container away from moisture|
|Shelf Life||2 years if sealed and store away from direct sun light.|
within 3 days after get the payment
9. Other Popular SARMs and Short Introduction:
|Enobosarm (Ostarine, MK-2866, GTx-024) - affects both muscle and
bone, intended mainly for osteoporosis but also general treatment
for andropause and reversing muscle sarcopenia in the elderly and
for cachexia in cancer patients.|
|LGD-4033||Pharmacological profile similar to that of enobosarm,
|Andarine (S4)||Partial agonist, intended mainly for treatment of benign prostatic
|GW-501516||It had been investigated as a potential treatment for obesity,
diabetes, dyslipidemia and cardiovascular disease.|
|AICAR||AICAR acts by entering nucleoside pools, significantly increasing
levels of adenosine during periods of ATP breakdown.|