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New Androgens Aicar / Acadesine Ampk Activator Steroid Hormone CAS 2627-69-2

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Zhuhaishi Shuangbojie Technology Co., Ltd
City: Zhuhai
Province/State: Guangdong
Country/Region: China
Tel: 86-185-78209857
Contact Person:
Mr luke

New Androgens Aicar / Acadesine Ampk Activator Steroid Hormone CAS 2627-69-2

Brand Name : nutritionsteroid
Model Number : kobe@chembj.com
Certification : Enterprise Standard
Place of Origin : China
MOQ : 10g
Price : Negotiation
Payment Terms : Bank Transfer, Western Union, MoneyGram, Bitcoin
Supply Ability : 1000kg/Month
Delivery Time : About a week to your door
Packaging Details : Hidden Package
CAS : 2627-69-2
MF : C9H14N4O5
MW : 258.23
Assay : 99%
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New Androgens Aicar/Acadesine Ampk Activator Steroid Hormone CAS 2627-69-2


1. Aicar introduction:

Product Name: AICAR/ Acadesine
Full name: 5-Aminoimidazole-4-carboxamide 1-β-D-ribofuranoside
Alias: AICA Riboside; Acadesine
CAS: 2627-69-2
MF: C9H14N4O5
MW: 258.23
EINECS: 220-097-5
Appearance: White powder
Purity: 99.8%
Usage: Glucose uptake stimulant; AMPK activator; AICAR is a nucleoside analogue that is able to enter nucleoside pools and is able to significantly increase levels of adenosine during periods of ATP breakdown. Adenosine-regulating agents (ARAs) hav e been recognized for therapeutic potential in myocardial ischemia. Cardioprotective.


2. Aicar Product Description:

AICAR (AICA-Riboside) strongly inhibits the transcription of PPAR&alpha and the coactivation of PPAR&alpha. In adipocyte studies it has been shown to antagonize lipolysis induced by isoprenaline and has been suggested for use in kinase cascade research. Additionally, research indicates that AICAR blocks the differentiation of 3T3-L1 (sc-2243) adipocytes. Studies demonstrate that AICAR can mimic the activity of insulin (sc-211647) by activating AMPK (AMP-activated protein kinase), and affecting the expression of PEPCK-M (PEPCK) and glucose-6-phosphatase (G6Pase). The 5-aminoimidazole-4-carboxamide ribonucleoside (ZMP) is the monophosphorylated derivative of AICA-Riboside, and it can serve as the substrate for the aminoimidazole carboxamide ribonucleotide transformylase/inosine monophosphate cyclohydrolase (ATIC). AICAR is an inhibitor of Hsp90, mTOR and p70 S6 Kinase.

AMP-activated protein kinase (AMPK) functions as a metabolic sensor that regulates lipid and glucose metabolism to maintain cellular energy homeostasis and to protect against metabolic stress.AICAR is a selective activator of AMPK in both hepatocytes and adipocytes. At 0.5 mM it inhibits the synthesis of fatty acids and sterols and inactivates HMG-CoA reductase in rat hepatocytes.AICAR (0.5 mM) inhibits insulin-stimulated glucose uptake to 62% of controls and reduces GLUT4 translocation 2.5-fold in 3T3-L1 adipocytes. It also blocks the expression of pro-inflammatory cytokines (TNF-α/IL-1β and IL-6), iNOS, COX-2, and MnSOD genes in glial cells and macrophages by inhibiting NFκB and C/EBP pathways.


3. Aicar Function:

AICAR also known as ZMP is an analog of AMP that is capable of stimulating AMP-dependent protein kinase activity (AMPK). AICAR is being clinically used to treat and
protect against cardiac ischemic injury. If left untreated, it may lead to a myocardial infarct.
Cardiac Ischemia is caused by insufficient blood flow and oxygen to the myocardium .
The drug was first used in the 1980’s as a method to preserve blood flow to the heart during surgery. Currently,
the drug has also been shown as a potential treatment for diabetes by increasing the
metabolic activity of tissues by changing the physical composition of muscle.


4. Aicar Product Application:

AICAR is a cell permeable activator of AMP-activated protein kinase (AMPK), a metabolic master regulator that is activated in times of reduced energy availability (high cellular AMP:ATP ratios) and serves to inhibit anabolic processes. In vivo, pharmacologic activation of AMPK with AICAR mimics exercise and triggers insulin-independent glucose uptake by skeletal muscle.

Cell-permeable, allosteric activator of AMP-activated protein kinase (AMPK). Augments proliferation, differentiation and mineralization of osteoblastic MC3T3-EI cells and attenuates psychosine-induced expression of proinflammatory cytokines and iNOS in astrocytes. Promotes osteogenic differentiation of hAMSCs and BM-MSCsin vitro.


5. AICAR Test Report(COA):


Item
SpecificationResult
AppearanceWhite powderComplies
Related substance (HPLC)Total impurity ≤0.5%
Max single impurity ≤0.1%
0.2%
0.06%
OdorCharacteristicComplies
Assay99%99.8%
Sieve analysis100% pass 80 meshComplies
Loss on Drying
Residue on Ignition
≤1.0%
≤1.0%
0.12%
0.09%
Heavy Metal<10ppmComplies
As<0.1ppm0.05ppm
Pb<0.1ppm0.05ppm
Cd<0.1ppm0.05ppm
Residual Solvents<100ppmComplies
Residual PesticideNegativeComplies
Microbiology
Total Plate Count<1000cfu/gComplies
Yeast & Mold<100cfu/gComplies
E.ColiNegativeComplies
SalmonellaNegativeComplies

6. What Is The Acadesine/AICAR/GP 1-110?

Acadesine (INN), also known as 5-aminoimidazole-4-carboxamide-1-β-D-ribofuranoside, AICA-riboside, and AICAR, is an AMP-activated protein kinase activator which is used for the treatment of acute lymphoblastic leukemia and may have applications in treating other disorders such as diabetes.
Acadesine is an adenosine regulating agent developed by PeriCor Therapeutics and licensed to Schering-Plough in 2007 for phase III studies. The drug is a potential first-in-class agent for prevention of reperfusion injury in CABG surgery. Schering began patient enrollment in phase III studies in May, 2009. The trial was terminated in late 2010 based on an interim futility analysis.

7. What Benefits of our Acadesine/AICAR/GP 1-110?

1.Applied in phamaceutical field, it is used as phamaceutical raw material to treat injuries from fall, infectious hepatitis and epidemic cerebrospinal meningitis.
2.Applied in healthcare field, it is used in the health products to nourish brain, protect liver and improve sleep quality.
3.Applied in comestics, it is used to promote skin metabolism and make skin more tender and firm.


8. Aicar Package&Storage:


Packaging Detail

0.5kgs/Al-foil bag

1.0kgs/Al-foil bag

2.0kgs/Al-foil bag

5.0 kgs/Al-foil bag

25.0 kgs/drum

or upon customers' request.

StorageStore in a well-closed container away from moisture
Shelf Life2 years if sealed and store away from direct sun light.
Delivery Detail

within 3 days after get the payment


9. Other Popular SARMs and Short Introduction:


Ostarine,MK-2866, Enobosarm
Enobosarm (Ostarine, MK-2866, GTx-024) - affects both muscle and bone, intended mainly for osteoporosis but also general treatment for andropause and reversing muscle sarcopenia in the elderly and for cachexia in cancer patients.
LGD-4033Pharmacological profile similar to that of enobosarm, Ostarine,MK-2866.
MK-677, Ibutamoren
Andarine (S4)Partial agonist, intended mainly for treatment of benign prostatic hypertrophy.
GW-501516It had been investigated as a potential treatment for obesity, diabetes, dyslipidemia and cardiovascular disease.
AICARAICAR acts by entering nucleoside pools, significantly increasing levels of adenosine during periods of ATP breakdown.


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