Dabrafenib/GSK2118436 CAS 1195765-45-7 Pharmaceutical Raw Material
for Skin Cancer
[Chemical name]Dabrafenib ;
[Molecular formula] C23H20F3N5O2S2
[Purity] Not less than 98%
[Loss on drying] Not more than 0.5%
[Storage]Store in a cool, dry place
(GSK2118436);Dabrafenib KB-57246;Debrafenib API|
|Appearance||White to slightly yellowish-white crystalline|
|Storage||Shading, confined preservation|
|Delivery||EMS, DHL, TNT, FedEx, UPS|
|Delivery time||within 24 hours upon receipt of payment|
|Product Category||Raf B protein kinase inhibitor;inhibitor;MAPK;Inhibitors|
Dabrafenib (trade name Tafinlar, GSK2118436) is a drug for the
treatment of cancers associated with a mutated version of the gene
BRAF. Dabrafenib acts as an inhibitor of the associated enzyme
B-Raf, which plays a role in the regulation of cell growth.
Dabrafenib has clinical activity with a manageable safety profile
in clinical trials of phase 1 and 2 in patients with
BRAF(V600)-mutated metastatic melanoma.
The Food and Drug Administration initially approved dabrafenib as a
single agent treatment for patients with BRAF
V600Emutation-positive advanced melanoma on May 30, 2013.Clinical
trial data demonstrated that resistance to dabrafinib and other
BRAF inhibitors occurs within 6 to 7 months.To overcome this
resistance, the BRAF inhibitor dabrafenib was combined with the MEK
inhibitor trametinib.On January 8, 2014, the FDA approved this
combination of dabrafenib and trametinib for BRAF V600E/K-mutant
Dabrafenib is used to treat a certain type of melanoma (a type of
skin cancer) that cannot be treated with surgery or that has spread
to other parts of the body. Dabrafenib is in a class of medications
called kinase inhibitors. It works by blocking the action of an
abnormal protein that signals cancer cells to multiply. This helps
stop the spread of cancer cells.
Other Small molecular API:
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