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Dabrafenib / GSK2118436 CAS 1195765-45-7 Pharmaceuticals for Skin Cancer

Dabrafenib / GSK2118436 CAS 1195765-45-7 Pharmaceuticals for Skin Cancer

Brand Name : nutritionsteroid
Model Number :
Certification : Enterprise Standard
Place of Origin : China
MOQ : 10g
Price : Negotiation
Payment Terms : Bank Transfer, Western Union, MoneyGram, Bitcoin
Supply Ability : 1000kg/Month
Delivery Time : About a week to your door
Packaging Details : Hidden Package
Shipping : FedEx,UPS,DHL,EMS
Payment : Western Union, T/T, Bitcoin
Time : 5-7 days
Assay : 99% min.
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Dabrafenib/GSK2118436 CAS 1195765-45-7 Pharmaceutical Raw Material for Skin Cancer

[Chemical name]Dabrafenib ; N-[3-[5-(2-Amino-4-pyrimidinyl)-2-(tert-butyl)-4-thiazolyl]-2-fluorophenyl]-2,6-difluorobenzenesulfonamide
[CAS NO.]1195765-45-7
[Molecular formula] C23H20F3N5O2S2
[Molecular Weight]519.56
[Purity] Not less than 98%
[Loss on drying] Not more than 0.5%
[Package] 1Kg/bag
[Storage]Store in a cool, dry place

Product nameDabrafenib
SynonymsDabrafenib;N-[3-[5-(2-Amino-4-pyrimidinyl)-2-(tert-butyl)-4-thiazolyl]-2-fluorophenyl]-2,6-difluorobenzenesulfonamide;Dabrafenib free base(GSK2118436A);Dabrafenib(GSK2118436);GSK2118436A;Dabrafenib (GSK2118436);Dabrafenib KB-57246;Debrafenib API
CAS NO1195765-45-7
AppearanceWhite to slightly yellowish-white crystalline
StorageShading, confined preservation
DeliveryEMS, DHL, TNT, FedEx, UPS
Delivery timewithin 24 hours upon receipt of payment
Product CategoryRaf B protein kinase inhibitor;inhibitor;MAPK;Inhibitors

Dabrafenib (trade name Tafinlar, GSK2118436) is a drug for the treatment of cancers associated with a mutated version of the gene BRAF. Dabrafenib acts as an inhibitor of the associated enzyme B-Raf, which plays a role in the regulation of cell growth. Dabrafenib has clinical activity with a manageable safety profile in clinical trials of phase 1 and 2 in patients with BRAF(V600)-mutated metastatic melanoma.

The Food and Drug Administration initially approved dabrafenib as a single agent treatment for patients with BRAF V600Emutation-positive advanced melanoma on May 30, 2013.Clinical trial data demonstrated that resistance to dabrafinib and other BRAF inhibitors occurs within 6 to 7 months.To overcome this resistance, the BRAF inhibitor dabrafenib was combined with the MEK inhibitor trametinib.On January 8, 2014, the FDA approved this combination of dabrafenib and trametinib for BRAF V600E/K-mutant metastatic melanoma.

Dabrafenib is used to treat a certain type of melanoma (a type of skin cancer) that cannot be treated with surgery or that has spread to other parts of the body. Dabrafenib is in a class of medications called kinase inhibitors. It works by blocking the action of an abnormal protein that signals cancer cells to multiply. This helps stop the spread of cancer cells.

Other Small molecular API:

Afatinib diMaleate439081-18-2
XL184 S-MALATE1140909-48-3

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