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Safety Ibutamoren Mesylate / Mk 677 SARMs Steroids for Muscle Building , CAS159752-10-0

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Safety Ibutamoren Mesylate / Mk 677 SARMs Steroids for Muscle Building , CAS159752-10-0

Brand Name : nutritionsteroid
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Place of Origin : China
MOQ : 10g
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Safety Ibutamoren Mesylate / Mk 677 CAS: 159752-10-0 Sarms for Muscle Building


1. MK-677 Quick detail:

Synonyms: Ibutamoren, CHEMBL13817, S1151_Selleck, MK-677

CAS No.: 159752-10-0

Molecular Weight: 624.77

Molecular Formula: C28H40N4O8S2

Purity: 99%

Product NameMK 677Other NameMK-0677;Ibutamoren
Purity99%min by HPLCCAS No.159752-10-0
AppearanceOff-yellow fine powderM.W.624.776
Melting Point170-172℃M.F.C27H36N4O5S
Specification≥99.5AssayHPLC;HNRM;LC-MS

2. MK-677 Description:

Ibutamoren (MK-0677) is a revolutionary non-peptide growth hormone (GH) secretagogue. MK-0677

triggers GH pulse discharge through the pituitary and hypothalamic receptors mimicking the GH

stimulating action of the endogenous hormone ghrelin. It has been widely demonstrated to upsurge

the release of, and creates sustained increases in plasma levels of several hormones including growth

hormone and IGF-1, but without affecting cortisol levels. It is currently under development as a potential

treatment for reduced levels of these hormones, such as in growth hormone deficient children or elderly

adults, and human studies have shown it to increase both muscle mass and bone mineral density,

making it a promising therapy for the treatment of frailty in the elderly. MK-0677 also alters basal

metabolism of body fat and so may have application in the future treatment of obesity.


MK-677 is an oral HGH SECRETAGOGUE that provides higher amplitude to the dozen or more

hgh pulses put out by the pituitary gland over the 25 hour half-life of the drug. Once daily

use before bed at a dose of 25mg provides all of the benefits of elevated HGH and Igf1 such as

deeper sleep with more vivid dreams, improved skin, faster hair and nail growth, fat loss, lean muscle

gain, increased strength, greater nitrogen retention the the skeletal muscles, greater protein synthesis,

etc.


Ibutamoren (MK-677, L-163,191) is a drug which acts as a potent, orally active secretagogue,mimicking the GH stimulating action of the endogenous hormone ghrelin.It has been demonstrated to increase the release of, and produces sustained increases in plasma levels of several hormones including , but without affecting cortisol levels.It is currently under development as a potential treatment for reduced levels of these hormones, such as in deficient children or elderly adults, and human studies have shown it to increase both muscle mass and bone mineral density, making it a promising therapy for the treatment of frailty in the elderly.It also alters metabolism of body fat and so may have application in the treatment of obesity.
Some mk-677 study shows the suggested mk-677 dosage is 25mgs-50mgs when it is the oral.


3. MK-677 Product Picture:

Safety Ibutamoren Mesylate / Mk 677 CAS: 159752-10-0 Sarms for Muscle Building


4. Benefits of MK-677 Ibutamoren :
In a study on it's effects on catabolic states, a once daily oral dose of 25mgs was given to healthy

young men subjected to short-term diet-induced nitrogen wasting. After 7 days of this dose, the

subjects showed a sustained increase in serum concentration of IGF-1 and Growth Hormone; in

addition, the nitrogen wasting was reversed, showing great potential for treatment of conditions

involving muscle wasting.
Trials testing the effects of this GHS on fighting obesity showed an increase in lean body mass, but neither total, nor visceral adipose tissue was effected. This study gave subjects 25mgs of Nutrobal

per day for 8 weeks. The subjects showed an increase in basal metabolic rate after 2 weeks, and an increase in serum levels of GH, IGF-1 and IGF-1 binding protein-3. Increase in lean body mass was hypothesized to be caused by an increase in calorie deposition into the muscle and appetite decrease

as opposed to reducing fat storage directly.
A study done for the treatment of osteoporosis and bone mineral density showed some increase in

bone density, so there is a true impact on bone mineral density. This can help with injury recovery

during your cycle.
Other possible benefits of Nutrobal are associated with improved sleep, improved complexion, increase

in energy levels, increase nitrogen retention, increase strength and an improved sense of well being.

In addition, some studies also suggest that an increased immune system response was caused by

Nutrobal (Mk-677), meaning it boosts the immune system to a degree.


5. How to Work

Growth hormone pulse intensity can be increased through 4 possible mechanisms:
Increasing GHRH (growth hormone releasing hormone) release.
Amplifying GHRH signaling in somatotrophs of the anterior pituitary gland.
Reducing somatostatin release (somatostatin turns off GH release).
Inhibiting of somatostatin receptor signaling.
Nutrobal (Mk-677) was found to work through all four of these mechanisms. After ingestion, Growth Hormone (GH) was shown to increase dose dependently, at doses starting at 5 milligrams (mgs) a day.


6. MK-677 COA:

TESTACCEPTANCE CRITERLARESULTS
TLCPositive
IdentificationUV spectrumPositive
IR spectrumPositive
CharacteristicsWhite to yellowish-white crystalline powderconform
Melting point32 ~ 37ºC33~36ºC
Specific optical rotation+77°~+82°+79.3°
Loss on drying≤0.5%0.15%
Assay97 ~ 103%99.08%
Free heptanoic acid≤0.2 %0.10%
Related substances≤2%Pass
Acetone ≤100ppmPass
Residual solvents(GC)Methanol ≤100ppmPass
Pyridine ≤100ppmPass
Particle sizePass

7. MK-677 Cycles

Here is an example of a Nutrobal + Cardarine + Andarine Cycle


Week
Nutrobal

Mk-677

Cardarine

GW-501516

Anrdarine

(S-4)

HCGenerate ES
N2Guard
125mgs/ED20mgs/ED25mgs/ED5tabs/ED5caps/ED
225mgs/ED20mgs/ED35mgs/ED5tabs/ED5caps/ED
325mgs/ED20mgs/ED35mgs/ED5tabs/ED5caps/ED
425mgs/ED20mgs/ED45mgs/ED5tabs/ED5caps/ED
525mgs/ED20mgs/ED45mgs/ED5tabs/ED5caps/ED
625mgs/ED20mgs/ED50mgs/ED3tabs/ED5caps/ED
725mgs/ED20mgs/ED50mgs/ED3tabs/ED5caps/ED
825mgs/ED20mgs/ED60mgs/ED2tabs/ED5caps/ED
925mgs/ED20mgs/ED60mgs/ED2tabs/ED5caps/ED
1025mgs/ED20mgs/ED70mgs/ED2tabs/ED5caps/ED

NOTE: Only ramp up andarine if you have the dosing schedule and side effects schedule properly

planned. Otherwise, stick to a lower dose. See this andarine (s4) dosing schedule.

Glossary:
ED = every day
mgs = milligrams
tabs = tablets
caps = capsules


This is an amazing cutting stack with Cardarine and Andarine, which will help melt off the stubborn fat and increase your muscle mass.

8. MK-677 Doses

Results have been shown from doses between 5-25mgs a day, dose dependent results should be

expected. Higher doses, over 50mgs, have been reported by some, but I don't see the need to

overdo it.

9. MK-677 Medical

Nutrobal (Mk-677) was found to be very safe and, in fact, showed to reduce tumors in mice,

which was hypothesized to be from an increased immune system response.


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